David S. Alberts,
Professor of Medicine; M.D., University of Virginia, 1966
shaywood@azcc.arizona.edu

Phase I and clinical pharmacokinetics of cancer chemotherapeutic and cancer prevention agents; drug interactions; clinical pharmacology; in vitro drug assay and biomarker studies in tumor cells; cancer chemopreventive agent pharmacology; and drug development trials.

Research Activities

1. In vitro screening of new anticancer and cancer chemopreventive agents against human tumor cell ines and fresh human tumors using cytotoxicity assays.

2.  Molecular, biochemical and cellular assays for evaluation of carcinogenic risk in human tissues, including colon/rectum, skin, buccal mucosa, cervix, prostate, and breast.

3. High performance liquid chromatography and atomic absorption spectrophotometry assays for anticancer and cancer chemopreventive agents in biological samples.

Publications (Query PubMed for this investigator)

Earnest DL, Einspahr JG, Alberts DS:  Protective role of wheat bran fiber: Data from marker trials.  Am J Med, 106:32S-37S, 1999.

Batta AK, Salen G, Rapole KR, Batta M, Batta P, Alberts D, Earnest D: Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. J Lipid Res, 40:1148-1154, 1999.

Martinez ME, Maltzman T, Marshall JR, Einspahr J, Reid ME, Sampliner R, Ahnen DJ, Hamilton SR, Albert DS:  Risk factors for ki-ras  protooncogene mutation in sporadic colorectal adenomas.  Cancer Res, in press, 1999.

Cheng L, Guan Y, Li L, Legersky RJ, Einspahr J, Bangert J, Alberts DS, Wei Q.  Expression of nucleotide excision repair genes measured simultaneously by multiple reverse transcription polymerase chain reaction.  Cancer Epidemiol. Biomarkers & Prevention, in press, 1999.

Martinez ME, Heddens D, Earnest DL, Bogert CL, Roe D, Einspahr J, Marshall JR, Alberts DS:  Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa.  J Natl Cancer Inst, 91:950-953, 1999.

Alberts DS, Dorr RT:  New perspectives on an old friend:  Optimizing carboplatin for the treatment of solid tumors.  Oncologist, 3:15-34, 1998.

Batta AK, Salen G, Holubec H, Brasitus TA, Alberts D, Earnest DL: Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps. Cancer Res, 58:1684-1687, 1998.

Batta AK, Salen G, Rapole KR, Batta M, Earnest D, Alberts D:  Capillary gas chromatographic analysis of serum bile acids as the n-butyl ester-trimethylsilyl ether derivatives.  J Chromatogr B, 706:337-341, 1998.

Bozzo PD, Vaught LC, Alberts DS, Thompson D, Bartels PH:  Nuclear morphometry in solar keratosis.  Analyt Quant Cytol Histol, 20:21-28, 1998.

Alberts DS, Slattery ML, Giovannucci E, Shike M, Garcia DJ:  Primary prevention of colon cancer with dietary and micronutrient interventions. Cancer, 83:1734-1739, 1998.

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