Douglas F. Larson,
Professor of Surgery, Professor of Pharmacology and Toxicology, Ph.D., University of Arizona, 1984.
dflarson@u.arizona.edu

Immunopharmacology: pharmacology and design of selective immunosuppressive therapies for solid organ transplantation and auto-immune diseases.

Research Activities

My research aims are to define the relationship between the immune system and the left ventricular function.  Recently, my research activities have focused on the role of iNOS and its product nitric oxide in cardiomyopathies related to immunological injury.  The models of cardiomyopathy being studied are secondly to HIV infection, autoimmunity, rejection, and aging.  The hypothesis of these studies is that myocardial dysfunction secondary to an immune-cytokine event is mediated by increased iNOS and NO activity.   In support of these studies, I have developed a system that can quantify the ventricular mechanics of the murine heart in vivo.

Publications (Query PubMed for this investigator)

Larson DF, D. Arzouman, L Klienert, V Patula, S Williams:  Comparison of Sarns 3M Bonded to Control Bypass Circuits in the Porcine Model.  Perfusion 15;13-20, 2000.

Larson DF, Eklund DK, Arabia F, Copeland JG:  Plamapheresis during cardiopulmonary bypass.  J. of Extracorporeal Technology, in press, 1999.

Sanders, DB and DF Larson:  Differential expression of eNOS and iNOS in septic shock.. JECT 31;118-124:1999

Yang B, Larson DF, Watson R.:  Age related changes in left ventricular function in the mouse: Analysis based on in vivo pressure-volume relationships. Am J Physiol., 277: H1906-1931, 1999.

Larson DF, D. Arzouman, L Klienert, V Patula, S Williams:  Sarns 3M Bonded to Control Bypass Circuits.  Proceedings of Am Acad of Cardiovascular Perfusion, accepted, 1998.

Larson, D.F., Gatewood, L.B., Bowers, M., Sethi, G., and Copeland, J.G.:  Assessment of left ventricular compliance during heart preservation.  Perfusion 13:67-75, 1998.

Clar, A., Bowers, M.C., and Larson, D.F.:  Derivation of sieving coefficients to determine the efficacy of the hemoconcentrator in removal of four inflammatory mediators produced during cardiopulmonary bypass.  ASAIO J. 43:163-170, 1997.

Larson, D.F, Bowers, M., and Schechner, H.W.:  Neutrophil activation during cardiopulmonary bypass in paediatric and adult patients.  Perfusion 11:21-27, 1996.

Pallas, F. and Larson, D.F.:  Cerebral blood flow in the diabetic patient.  Perfusion 11:363-370, 1996.

Gatewood, L.B., Larson, D.F., Bowers, M.C., Bond, S., Cardy, A., Sethi, G.K., and Copeland, J.G.:  A novel mechanism for cyclosporine: inhibition of myocardial ischemia and reperfusion injury in a heterotopic rabbit heart transplant model.  J. Heart Lung Transplant 15:936-947, 1996.

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