Paul F. McDonagh,
Professor of Surgery, Ph.D., University of California, Davis, 1976
pmcdonag@u.arizona.edu

Cardiovascular interactions with blood in the etiology of ischemia-reperfusion injury in the heart and brain.

Research Activities

Cardiovascular Complications of Diabetes. These NIH-funded studies aim to determine the role of blood-microvessel interactions in the excessive injury response of the diabetic heart to ischemia-reperfusion.
The Acute Inflammatory Response in Cardiac Surgery. Laboratory and clinical investigations of the mechanisms by which platelets and leukocytes contribute to acute inflammation following cardiac surgery.
The Cerebral Microciruclation in Stroke. These studies aim to determine the role of the cerebral microcirculation in the etiology of reperfusion injury following stroke.

Publications (Query PubMed for this investigator)

Ruehl ML, Orozco JA, Stoker MB, McDonagh PF, Coull BM and LS Ritter. Protective Effects of Inhibiting Both Blood and Vascular Selectins After Stroke and Reperfusion. Neurological Research 24: 226-232, 2002.

Gale SC, JY Hokama, LS Ritter, G Davis-Gorman, JG Copeland and PF McDonagh. Pentoxifylline Reduces Leukocyte Accumulation in the Coronary Microcirculation Early in the Reperfusion of Cold Cardioplegia-Protected Hearts. Annals of Thoracic Surgery. 71: 1305-1311, 2001.

McDonagh P, Cerney K, Hokama J, Lai G, Gonzales R, Davis-Gorman G and J Copeland. Perflubron Emulsion Reduces Inflammation During Extracorporeal Circulation. Journal of Surgical Research. 99: 7-16, 2001

McDonagh PF and Hokama JY: Microvascular transport and exchange in the diabetic heart. Microcirculation. 7:163-181, 2000.

Close This Window