Eugene Morkin,
Professor of Medicine, M.D., University of Oklahoma, 1959

Molecular basis for cardiac development and contractile function.

Research Activities

Molecular basis for cardiac growth and contractile function.
Cardiac growth and contractile function are closely linked during development and in response to physiological stimuli. The molecular mechanisms underlying these processes are studied in the embryonic heart and in animal models of heart disease. The studies involve the use of recombinant DNA techniques and cultured heart cells to identify potential sites of action for new cardiovascular drugs.

Publications (Query PubMed for this investigator)

Morkin, E., Pennock, G., Spooner, P.H., Bahl, J.J., and Goldman, S. (2002). Clinical and experimental studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in heart failure. Thyroid, 12:527-533.

Morkin, E., Pennock, G., Spooner, P.H., Bahl, J.J., Underhill Fox, K., and Goldman, S. (2002). Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure. Cardiology, 97:218-225.

Adamson, C., Niu, S., Bahl, J.J., and Morkin, E.: Cloning and characterization of P110, a novel small nucleolar U3 ribonucleoprotein, expressed in early development. Exp. Cell Res., 263:55-64, 2001.

Maitra, N., Flink, I.L., Bahl, J.J., and Morkin, E.: Expression of a and b integrins during terminal differentiation of cardiomyocytes. J. Cardiovasc. Res., 47:715-725, 2000.

Flink, I.F., Oana, S., Maitra, N., Bahl, J.J., and Morkin, E.: Changes in E2F complexes containing retinoblastoma protein family members and increased cyclin-dependent kinase inhibitor activity during terminal differentiation of cardiomyocytes. J. Mol. Cell. Cardiol., 30:563-578,1998.

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