Mark L. Witten,
Research Professor of Pediatrics, Ph.D., Indiana University, 1983
mwitten@peds.arizona.edu

Acute and chronic exposure to environmental toxins and their effect on the pulmonary system, including host cellular defense system.

Research Activities

My research is concerned with the effects of environmental toxins on the lungs both in a chronic and acute situation.  We also are investigating the effects of these environmental toxins on lung cells such as alveolar macrophages.  We are currently studying superoxide production, tumor necrosis factor alpha, and cytochrome compounds produced by alveolar macrophages.  We also have an interest in the effects of chronic  environmental toxin exposure on lung growth and development measured by morphological and fractal techniques.

Publications (Query PubMed for this investigator)

Fernandez A, Davis SB, Wendt JOL, Cenni R, Young RS, Witten ML: Potential  respiratory distress due to the composition of particulate emissions from biomass co-combustion with coal. NATURE, in press, 2001.

Robledo RF, Young RS, Lantz RC, Witten ML: Short-term pulmonary response to inhaled JP-8 jet fuel aerosol in mice. TOXICOLOGIC PATHOLOGY, 28:656-663, 2000.

Witten ML, Watson RR: Environmental Tobacco Smoke. CRC Press, Boca Raton, Florida, 2000. ISBN 0-8493-0311-7.

Wang S, Witten ML: Neurokinin-1 (NK1) receptor activation changes eicosanoid generation of acute respiratory distress syndrome. PROCEEDINGS OF THE 2000 TACHYKININS INTERNATIONAL CONFERENCE, La Grande Motte, France.

Witzmann FA, Bauer MD, Fieno AM, Fultz CD, Grant RA, Keough TW, Kornguth SE, Lacey MP, Siegel FL, Sun Y, Wright LS, Young RS, Witten ML: Proteomic analysis of simulated occupational jet fuel exposure in the lung. ELECTROPHORESIS, 20:3659-3669, 1999.

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