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Although chronic skeletal pain can have a marked impact on an individual's health relatively little is known about the specific populations of peripheral nerve fibers that drive and/or modulate bone pain. Although skeletal pain is caused by a diverse group of disorders and injuries including fracture, osteoarthritis and osteoporosis, what these disorders share in common is that they frequently impair physical function and induce long term disability. Given the burden that skeletal pain places on society what is surprising is how little we know about the specific mechanisms that drive skeletal pain. In large part, this is due to the lack of available animal models of skeletal pain that closely mirror the human condition. The goal of our lab is characterize the organization and phenotype of nerve fibers that innervate the bone, how the different populations of nerve fibers reorganize as the bone remodels, whether trauma and aging of bone induce changes in the nerves that innervate the bone and whether these changes play unique role(s) in driving musculoskeletal pain.
Jimenez-Andrade JM, Herrera MB, Ghilardi JR, Vardanyan M, Melemedjian OK, Mantyh PW. (2008). Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Mol Pain. Mar 19;4:10.
Freeman KT, Koewler NJ, Jimenez-Andrade JM, Buus RJ, Herrera MB, Carl D. Martin CD, Ghilardi, JR, Kuskowski MA, Mantyh PW. (2008). A fracture pain model in the rat: adaptation of the closed femur fracture model to study skeletal pain. Anesthesiology. 108:473-83.
Koewler NJ, Freeman KT, Buus RJ, Herrera MB, Jimenez-Andrade JM, Ghilardi JR, Peters CM, Sullivan LJ, Kuskowski MA, Lewis JL, Mantyh PW. (2007). Effects of a Monoclonal Antibody Raised Against Nerve Growth Factor on Skeletal Pain and Bone Healing Following Fracture of the C57BL/6J Mouse Femur. Journal of Bone Mineral Research. 22:1732-42.
Jimenez-Andrade JM, Martin CD, Koewler NJ, Freeman KT, Sullivan LJ, Halvorson KG, Barthold CM, Peters CM, Buss RJ, Mantyh PW. (2007). Nerve growth factor sequestering therapy attenuates skeletal pain following fracture. Pain; 133:183-96.
Martin CD, Jimenez-Andrade JM, Ghilardi J, Mantyh PW. (2007). Organization of a unique net-like meshwork of CGRP+ fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain. Neuroscience letters. 427:148-52.
Peters CM, Jimenez-Andrade JM, Jonas BM, Sevcik MA, Koewler NJ, Ghilardi JR, Wong GY, Mantyh PW. (2007). Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells. Experimental Neurology. 2007;203:42-54.
Peters CM, Jimenez-Andrade JM, Kuskowski MA, Ghilardi JR, Mantyh PW. (2007). An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat. Brain Research. 1168:46-59.
Jimenez-Andrade JM, Peters CM, Mejia NA, Ghilardi JR, Kuskowski MA, Mantyh PW. (2006). Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat. Neuroscience Letters. 405:62-7.
Jimenez-Andrade JM, Lundstrom L, Sollenberg UE, Langel U, Castaneda-Hernandez G, Carlton SM. (2006). Activation of peripheral galanin receptors: Differential effects on nociception. Pharmacology Biochemestry Behavior. 85:273-80.
Jimenez-Andrade JM, Zhou S, Yamani A, de Ita SV, Castaneda-Hernandez G, Carlton SM (2005). Mechanism by which peripheral galanin increases acute inflammatory pain. Brain Research.1056:113-7.
Jimenez-Andrade JM, Zhou S, Du J, Yamani A, Grady JJ, Castaneda-Hernandez G, Carlton SM. (2004). Pro-nociceptive role of peripheral galanin in inflammatory pain. Pain.110:10-21.
Jimenez-Andrade JM, Ortiz MI, Perez-Urizar J, Aguirre-Banuelos P, Granados-Soto V, Castaneda-Hernandez G. (2003). Synergistic effects between codeine and diclofenac after local, spinal and systemic administration. Pharmacology Biochemistry Behavior. 76:463-71.