Professor and Head of Pharmacology, University of Pittsburgh, 1969Dr. Sipes' research actvities center around the disposition and metabolism of environmental chemicals. He is particularly interested in how various chemicals are metabolized to toxic metabolites that damage the liver and ovary, as well as other tissues. It is often a metabolite of the chemical that is responsible for the tissue injury produced by exposure to the chemical. Species differences in the metabolism of the chemical (i.e. rate or route) may explain why one species is susceptible and another is resistant to the toxic effects of the chemical. Of particular interst in understanding how humans metabolize a chemical.
Figure 1
Lack of human hepatic microsomes to form the glucuronide of the carcinogen BMP (2,2-bis[bromomethyl]-1,3-propane diol)
Figure 2
Inhibitory effects of N-alkylpyridinium compounds ("green solvents") on the transport of the antidiabetic drug of metformin by human Organic Cation Transporter 2
Api, A-M, Lapczynski, A., Isola D.A. and Sipes IG. In vitro penetration and subchronic toxicity α Methyl-1,3-benzodioxole-5-propionaldehyde. Food Chem Toxicol. 45(5): 702-7, May, 2007.
Kuester R.K., Solyom A.M., Rodriguez V.P., Sipes I. G. The Effects of Dose, Route, and Repeated Dosing on the Disposition and Kinetics of Tetrabromobisphenol A in Male F-344 Rats. Toxicol. Sci. 96:237-245, 2007.
Hoyer P.B., Sipes I.G. Development of an animal model for ovotoxicity using 4-vinylcyclohexene: A case study. Article for Birth Defects Research Part B. Developmental and Reproductive Toxicology, 80:113-125, 2007.
Rajapaksa K.S., Sipes I.G., Hoyer P.B. Involvement of Microsomal Epoxide Hydrolase Enzyme in Ovotoxicity Caused by 7,12-Dimethylbenz[a] anthracene. Toxicol. Sci. 96:327-334, 2007.
Knudsen G., Jacobs L.J., Kuester R. K., Sipes, I.G. Absorption, distribution metabolism and excretion of intravenously and orally administered Tetrabromobisphenol A [2,3 Dibromopropyl Ether] in male Fischer-344 rats. Toxicology. 237; 158-167, 2007.
Sipes I.G., Knudsen G.A., Kuester R.K. The effects of dose and route on the toxicokinetics and disposition of 1-butyl-3-methylimidazolium chloride in male F-344 rats and female B6C3F1 mice. Drug Metab. Dispos. 36(2):284-93, 2008.
Isola D., Kimber i., Sarlo K., Lalko J., Sipes I.G. Chemical respiratory allergy and occupational asthma: what are the key areas of uncertainty? J Appl Toxicol. 28(3):249-53, 2008.
Keating A.F., Sipes I.G., Hoyer P.B. Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice. Toxicol. Appl. Pharmacol., 230(1):109-16, 2008.
Keating A.F., Rajapaksa K.S., Sipes I.G., Hoyer P.B. Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to BCD exposure. Toxicol. Sci. 105(2):351-9, 2008.
Hoehle S.I., Knudsen G, Sanders J.M., Sipes I.G. Absorption, distribution, metabolism and excretion of 2,2-bis[bromomethyl]-1,3,-propanediol in male Fischer-344 rats. Drug Metab Dispos, 2008.
Kuester R.K. and Sipes I.G. Prediction of metabolic clearance of Bisphenol A (4,4-dihydroxy-2,2,-diphenylpropane) using cryopreserved humane hepatocytes. Drug Metab. And Dispo. 35; 1910-1915, 2007.