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Dr. Sipes' research actvities center around the disposition and metabolism of environmental chemicals. He is particularly interested in how various chemicals are metabolized to toxic metabolites that damage the liver and ovary, as well as other tissues. It is often a metabolite of the chemical that is responsible for the tissue injury produced by exposure to the chemical. Species differences in the metabolism of the chemical (i.e. rate or route) may explain why one species is susceptible and another is resistant to the toxic effects of the chemical. Of particular interst in understanding how humans metabolize a chemical.
Lack of human hepatic microsomes to form the glucuronide of the carcinogen BMP (2,2-bis[bromomethyl]-1,3-propane diol)
Inhibitory effects of N-alkylpyridinium compounds ("green solvents") on the transport of the antidiabetic drug of metformin by human Organic Cation Transporter 2
Kuester R.K., Solyom A.M., Rodriguez V.P., Sipes I. G. The Effects of Dose, Route, and Repeated Dosing on the Disposition and Kinetics of Tetrabromobisphenol A in Male F-344 Rats. Toxicol. Sci. 96:237-245, 2007.
Hoyer P.B., Sipes I.G. Development of an animal model for ovotoxicity using 4-vinylcyclohexene: A case study. Article for Birth Defects Research Part B. Developmental and Reproductive Toxicology, 80:113-125, 2007.
Sipes I.G., Knudsen G.A., Kuester R.K. The effects of dose and route on the toxicokinetics and disposition of 1-butyl-3-methylimidazolium chloride in male F-344 rats and female B6C3F1 mice. Drug Metab. Dispos. 36(2):284-93, 2008.
Hoehle S.I., Knudsen G, Sanders J.M., Sipes I.G. Absorption, distribution, metabolism and excretion of 2,2-bis[bromomethyl]-1,3,-propanediol in male Fischer-344 rats. Drug Metab Dispos, 37(2):408-416, 2009.
Cheng Y., Wright S.H., Hooth M.J., and Sipes I.G. Characterization of the disposition and toxicokinetics of N-Butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos 37:1-8, 2009.
Goodman, J.E., Witorsch, R.J., McConnell, E.E., Sipes, I.G., Slayton, T.M, Yu, C.J., Franz, A.M., Rhombert, L.R. Weight-of-evidence evaluation of reproductive and developmental effects of low doses of bisphenol A. Crit Rev Toxicol 39(1):1-75, 2009.
Knudsen, G.A., Cheng, Y., Kuester, R.K., Hooth, M.J., Sipes, I.G. The effects of dose and route on the disposition and kinetics of 1-Butyl-1-methylpyrrolidinium chloride in male F-344 rats. Drug Metab Dispos, 37(11):2171-7, 2009.
Rad, G, Hoehle, S.I., Kuester, R.K., Sipes, I.G. In vitro glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediol by microsomes and hepatocytes from rats and humans. Drug Metab Dispos, 38(6): 957-962, 2010.