The University of Arizona
Department of Pharmacology

Marilyn Halonen

Halonen Professor of Pharmacology, Faculty Member, Arizona Respiratory Center
Ph.D., University of Arizona, 1973

College of Medicine 2342A
(520) 626-6537
mhalonen@arc.arizona.edu

 

Research Interests

Research Activities

Research aims are to determine the major causative factors of asthma, the genetic mechanisms by which asthma develops and the environmental influences on the maturing genetics of immune development that contribute to asthma susceptibility. Approaches involve dissecting the immune cell activities and mechanistic pathways that explain associations between asthma phenotype and gene variant information.

Selected Publications

Krishnan S, Craven M, Welliver R, Ahmad N, Halonen M (2003) Differences in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus in Adult and Newborn Mononuclear Cells. J Infect Dis. 188:433-9.

Brown MA, Rad PY, Halonen MJ (2003) Method of birth alters interferon-gamma and interleukin-12 production by cord blood mononuclear cells. Pediatric Allergy Immunol. 14:106-111.

Wright AL, Stern DA, Halonen M (2001) The association of allergic sensitization in mother and child in breast-fed and formula-fed infants. Adv Exp Med Biol 501:249-55.

Schweiger A, Stern D, Baldini M, Lohman IC, Martinez FD, Halonen M (2001) Differences in proliferation of the hematopoietic cell lineTF-1 and cytokine production by peripheral blood leukocytes induced by two naturally occurring forms of human interleukin-3. J Allergy Clin Immunol 107:505-10.

LeVan TD, Bloom JW, Bailey TJ, Karp CL, Halonen M, Martinez FD, Vercelli D (2001) A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 167:5838-44.

Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland S, Erickson RP, von Mutius E, Martinez FD (2000) A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of Caucasian children. J Allergy Clin Immunol 105:506-13.

Ball TM, Anderson D, Minto J, Halonen M. Cortisol circadian rhythms and stress responses in infants at risk of allergic disease. J Allergy Clin Immunol. 117(2):306-11 (2006).

LeVan TD, Guerra S, Klimecki W, Vasquez MM, Lohman IC, Martinez, FD, Halonen M, Wright AL. The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy. Genes Immun.7(1):77-80 (2006).

Halonen M, Stern D. Predicting the course of asthma. Allergy and Asthma Proc 27:328-331 (2006).

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